SINGLE-MOLECULE FRET UNMASKS STRUCTURAL SUBPOPULATIONS AND CRUCIAL MOLECULAR EVENTS DURING FUS LOW-COMPLEXITY DOMAIN PHASE SEPARATION

Single-molecule FRET unmasks structural subpopulations and crucial molecular events during FUS low-complexity domain phase separation

Abstract Biomolecular condensates formed via phase separation of proteins and nucleic acids are thought to be associated with a wide range of cellular functions and dysfunctions.We dissect critical molecular events associated with phase separation of an intrinsically disordered prion-like low-complexity domain of Fused in Sarcoma by performing sing

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Students as Partners in the Scholarship of Teaching and Learning

This essay reflects upon lessons learning from engaging students as partners in the scholarship of teaching and learning (SoTL).The project described Beard here aimed to engage undergraduate students in SoTL research-based learning using the case study teaching method.Student partners were actively involved in synthesis of original case studies for

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Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke.

Adipose-derived mesenchymal stem cells (AdMSCs) have been reported to ameliorate neurological deficits after acute ischemic stroke.As neuregulin 1 (NRG1, or heregulin 1), a growth factor with versatile functions in the central nervous system, has demonstrated protective effects against ischemic brain injuries, we have generated NRG1-overexpressing

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